A team of researchers at Purdue University recently showed that a new technology called biodynamic imaging accurately predicts the effectiveness of chemotherapy treatment for dogs with B-cell lymphoma.  Biodynamic imaging measures intracellular motion within living tumor tissue freshly collected by surgical biopsy from a patient with cancer.  Distinct patterns of intracellular motion are then correlated with sensitivity or resistance of that cancer to a drug or combination of drugs.

Investigators

  • David D. Nolte, PhD
  • John J. Turek, PhD
  • Michael O. Childress, DVM

Three key benefits to the findings

  • Offers a platform for predicting the effectiveness of cancer chemotherapy drugs before they are given, thus potentially avoiding ineffective, toxic treatments.
  • Provides evidence that cancer-bearing pet dogs can be effective animal models in preclinical research involving precision medicine.
  • May provide a new method for screening cancer drugs for efficacy before they are entered into clinical trials.